Effect of Lactobacillus paracasei subsp. paracasei, L. casei 431 on immune response to influenza vaccination and upper respiratory tract infections in healthy adult volunteers: a randomized, double-blind, placebo-controlled, parallel-group study.
Identifieur interne : 000135 ( Main/Exploration ); précédent : 000134; suivant : 000136Effect of Lactobacillus paracasei subsp. paracasei, L. casei 431 on immune response to influenza vaccination and upper respiratory tract infections in healthy adult volunteers: a randomized, double-blind, placebo-controlled, parallel-group study.
Auteurs : Lillian Jespersen ; Inge Tarnow ; Dorte Eskesen ; Cathrine Melsaether Morberg [Oman] ; Birgit Michelsen ; Susanne Bügel ; Lars Ove Dragsted ; Ger T. Rijkers ; Philip C. CalderSource :
- The American journal of clinical nutrition [ 1938-3207 ] ; 2015.
Descripteurs français
- KwdFr :
- Adolescent, Adulte, Adulte d'âge moyen, Allemagne, Animaux, Anticorps antiviraux (sang), Danemark, Femelle, Grippe humaine (), Grippe humaine (immunologie), Humains, Indice de masse corporelle, Infections de l'appareil respiratoire (), Infections de l'appareil respiratoire (immunologie), Jeune adulte, Lactobacillus casei, Lait, Mâle, Méthode en double aveugle, Numération de colonies microbiennes, Probiotiques (administration et posologie), Résultat thérapeutique, Tests d'inhibition de l'hémagglutination, Vaccination, Vaccins antigrippaux (usage thérapeutique), Volontaires sains.
- MESH :
- administration et posologie : Probiotiques.
- immunologie : Grippe humaine, Infections de l'appareil respiratoire.
- sang : Anticorps antiviraux.
- usage thérapeutique : Vaccins antigrippaux.
- Adolescent, Adulte, Adulte d'âge moyen, Allemagne, Animaux, Danemark, Femelle, Grippe humaine, Humains, Indice de masse corporelle, Infections de l'appareil respiratoire, Jeune adulte, Lactobacillus casei, Lait, Mâle, Méthode en double aveugle, Numération de colonies microbiennes, Résultat thérapeutique, Tests d'inhibition de l'hémagglutination, Vaccination, Volontaires sains.
- Wicri :
English descriptors
- KwdEn :
- Adolescent, Adult, Animals, Antibodies, Viral (blood), Body Mass Index, Colony Count, Microbial, Denmark, Double-Blind Method, Female, Germany, Healthy Volunteers, Hemagglutination Inhibition Tests, Humans, Influenza Vaccines (therapeutic use), Influenza, Human (immunology), Influenza, Human (prevention & control), Lactobacillus casei, Male, Middle Aged, Milk, Probiotics (administration & dosage), Respiratory Tract Infections (immunology), Respiratory Tract Infections (prevention & control), Treatment Outcome, Vaccination, Young Adult.
- MESH :
- chemical , blood : Antibodies, Viral.
- chemical , therapeutic use : Influenza Vaccines.
- geographic : Denmark, Germany.
- administration & dosage : Probiotics.
- immunology : Influenza, Human, Respiratory Tract Infections.
- prevention & control : Influenza, Human, Respiratory Tract Infections.
- Adolescent, Adult, Animals, Body Mass Index, Colony Count, Microbial, Double-Blind Method, Female, Healthy Volunteers, Hemagglutination Inhibition Tests, Humans, Lactobacillus casei, Male, Middle Aged, Milk, Treatment Outcome, Vaccination, Young Adult.
Abstract
BACKGROUND
Probiotics can modulate the immune system in healthy individuals and may help reduce symptoms related to respiratory infections.
OBJECTIVE
The objective of the study was to investigate the effect of the probiotic strain Lactobacillus paracasei subsp. paracasei, L. casei 431 (Chr. Hansen A/S) (hereafter, L. casei 431) on immune response to influenza vaccination and respiratory symptoms in healthy adults.
DESIGN
A randomized double-blind, placebo-controlled trial was conducted in 1104 healthy subjects aged 18-60 y at 2 centers in Germany and Denmark. Subjects were randomly assigned to receive an acidified milk drink containing ≥10(9) colony-forming units of L. casei 431 (n = 553) or placebo (n = 551) for 42 d. After 21 d, subjects received the seasonal influenza vaccination. The primary outcome was seroprotection rate (anti-influenza antibody titers by hemagglutination inhibition) 21 d after vaccination. Other outcomes were seroconversion rate and mean titers, influenza A-specific antibodies and incidence, and duration and severity of upper respiratory symptoms. Antibiotic use and use of health care resources were recorded.
RESULTS
There was no effect of L. casei 431 on immune responses to influenza vaccination. Generalized linear mixed modeling showed a shorter duration of upper respiratory symptoms in the probiotic group than in the placebo group (mean ± SD: 6.4 ± 6.1 vs. 7.3 ± 9.7 d, P = 0.0059) in the last 3 wk of the intervention period. No statistically significant differences were found for incidence or severity.
CONCLUSIONS
Daily consumption of L. casei 431 resulted in no observable effect on the components of the immune response to influenza vaccination but reduced the duration of upper respiratory symptoms. The trial was registered at www.isrctn.com as ISRCTN08280229.
DOI: 10.3945/ajcn.114.103531
PubMed: 25926507
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Effect of Lactobacillus paracasei subsp. paracasei, L. casei 431 on immune response to influenza vaccination and upper respiratory tract infections in healthy adult volunteers: a randomized, double-blind, placebo-controlled, parallel-group study.</title><author><name sortKey="Jespersen, Lillian" sort="Jespersen, Lillian" uniqKey="Jespersen L" first="Lillian" last="Jespersen">Lillian Jespersen</name><affiliation><nlm:affiliation>From Chr. Hansen A/S, Hørsholm, Denmark (LJ, IT, DE, CMM, and BM); Department of Nutrition, Exercise and Sports, Faculty of Science, University of Copenhagen, Copenhagen, Denmark (SB and LOD); Department of Sciences, Roosevelt Academy, Middelburg, The Netherlands (GTR); Human Development and Health Academic Unit, Faculty of Medicine, University of Southampton, Southampton, United Kingdom, and National Institute for Health Research Southampton Biomedical Research Centre, University Hospital Southampton National Health Service Foundation Trust and University of Southampton, Southampton, United Kingdom (PCC).</nlm:affiliation><wicri:noCountry code="subField">United Kingdom (PCC)</wicri:noCountry></affiliation></author><author><name sortKey="Tarnow, Inge" sort="Tarnow, Inge" uniqKey="Tarnow I" first="Inge" last="Tarnow">Inge Tarnow</name><affiliation><nlm:affiliation>From Chr. Hansen A/S, Hørsholm, Denmark (LJ, IT, DE, CMM, and BM); Department of Nutrition, Exercise and Sports, Faculty of Science, University of Copenhagen, Copenhagen, Denmark (SB and LOD); Department of Sciences, Roosevelt Academy, Middelburg, The Netherlands (GTR); Human Development and Health Academic Unit, Faculty of Medicine, University of Southampton, Southampton, United Kingdom, and National Institute for Health Research Southampton Biomedical Research Centre, University Hospital Southampton National Health Service Foundation Trust and University of Southampton, Southampton, United Kingdom (PCC).</nlm:affiliation><wicri:noCountry code="subField">United Kingdom (PCC)</wicri:noCountry></affiliation></author><author><name sortKey="Eskesen, Dorte" sort="Eskesen, Dorte" uniqKey="Eskesen D" first="Dorte" last="Eskesen">Dorte Eskesen</name><affiliation><nlm:affiliation>From Chr. Hansen A/S, Hørsholm, Denmark (LJ, IT, DE, CMM, and BM); Department of Nutrition, Exercise and Sports, Faculty of Science, University of Copenhagen, Copenhagen, Denmark (SB and LOD); Department of Sciences, Roosevelt Academy, Middelburg, The Netherlands (GTR); Human Development and Health Academic Unit, Faculty of Medicine, University of Southampton, Southampton, United Kingdom, and National Institute for Health Research Southampton Biomedical Research Centre, University Hospital Southampton National Health Service Foundation Trust and University of Southampton, Southampton, United Kingdom (PCC).</nlm:affiliation><wicri:noCountry code="subField">United Kingdom (PCC)</wicri:noCountry></affiliation></author><author><name sortKey="Morberg, Cathrine Melsaether" sort="Morberg, Cathrine Melsaether" uniqKey="Morberg C" first="Cathrine Melsaether" last="Morberg">Cathrine Melsaether Morberg</name><affiliation wicri:level="1"><nlm:affiliation>From Chr. Hansen A/S, Hørsholm, Denmark (LJ, IT, DE, CMM, and BM); Department of Nutrition, Exercise and Sports, Faculty of Science, University of Copenhagen, Copenhagen, Denmark (SB and LOD); Department of Sciences, Roosevelt Academy, Middelburg, The Netherlands (GTR); Human Development and Health Academic Unit, Faculty of Medicine, University of Southampton, Southampton, United Kingdom, and National Institute for Health Research Southampton Biomedical Research Centre, University Hospital Southampton National Health Service Foundation Trust and University of Southampton, Southampton, United Kingdom (PCC). dkcmm@chr-hansen.com.</nlm:affiliation><country wicri:rule="url">Oman</country></affiliation></author><author><name sortKey="Michelsen, Birgit" sort="Michelsen, Birgit" uniqKey="Michelsen B" first="Birgit" last="Michelsen">Birgit Michelsen</name><affiliation><nlm:affiliation>From Chr. Hansen A/S, Hørsholm, Denmark (LJ, IT, DE, CMM, and BM); Department of Nutrition, Exercise and Sports, Faculty of Science, University of Copenhagen, Copenhagen, Denmark (SB and LOD); Department of Sciences, Roosevelt Academy, Middelburg, The Netherlands (GTR); Human Development and Health Academic Unit, Faculty of Medicine, University of Southampton, Southampton, United Kingdom, and National Institute for Health Research Southampton Biomedical Research Centre, University Hospital Southampton National Health Service Foundation Trust and University of Southampton, Southampton, United Kingdom (PCC).</nlm:affiliation><wicri:noCountry code="subField">United Kingdom (PCC)</wicri:noCountry></affiliation></author><author><name sortKey="Bugel, Susanne" sort="Bugel, Susanne" uniqKey="Bugel S" first="Susanne" last="Bügel">Susanne Bügel</name><affiliation><nlm:affiliation>From Chr. Hansen A/S, Hørsholm, Denmark (LJ, IT, DE, CMM, and BM); Department of Nutrition, Exercise and Sports, Faculty of Science, University of Copenhagen, Copenhagen, Denmark (SB and LOD); Department of Sciences, Roosevelt Academy, Middelburg, The Netherlands (GTR); Human Development and Health Academic Unit, Faculty of Medicine, University of Southampton, Southampton, United Kingdom, and National Institute for Health Research Southampton Biomedical Research Centre, University Hospital Southampton National Health Service Foundation Trust and University of Southampton, Southampton, United Kingdom (PCC).</nlm:affiliation><wicri:noCountry code="subField">United Kingdom (PCC)</wicri:noCountry></affiliation></author><author><name sortKey="Dragsted, Lars Ove" sort="Dragsted, Lars Ove" uniqKey="Dragsted L" first="Lars Ove" last="Dragsted">Lars Ove Dragsted</name><affiliation><nlm:affiliation>From Chr. Hansen A/S, Hørsholm, Denmark (LJ, IT, DE, CMM, and BM); Department of Nutrition, Exercise and Sports, Faculty of Science, University of Copenhagen, Copenhagen, Denmark (SB and LOD); Department of Sciences, Roosevelt Academy, Middelburg, The Netherlands (GTR); Human Development and Health Academic Unit, Faculty of Medicine, University of Southampton, Southampton, United Kingdom, and National Institute for Health Research Southampton Biomedical Research Centre, University Hospital Southampton National Health Service Foundation Trust and University of Southampton, Southampton, United Kingdom (PCC).</nlm:affiliation><wicri:noCountry code="subField">United Kingdom (PCC)</wicri:noCountry></affiliation></author><author><name sortKey="Rijkers, Ger T" sort="Rijkers, Ger T" uniqKey="Rijkers G" first="Ger T" last="Rijkers">Ger T. Rijkers</name><affiliation><nlm:affiliation>From Chr. Hansen A/S, Hørsholm, Denmark (LJ, IT, DE, CMM, and BM); Department of Nutrition, Exercise and Sports, Faculty of Science, University of Copenhagen, Copenhagen, Denmark (SB and LOD); Department of Sciences, Roosevelt Academy, Middelburg, The Netherlands (GTR); Human Development and Health Academic Unit, Faculty of Medicine, University of Southampton, Southampton, United Kingdom, and National Institute for Health Research Southampton Biomedical Research Centre, University Hospital Southampton National Health Service Foundation Trust and University of Southampton, Southampton, United Kingdom (PCC).</nlm:affiliation><wicri:noCountry code="subField">United Kingdom (PCC)</wicri:noCountry></affiliation></author><author><name sortKey="Calder, Philip C" sort="Calder, Philip C" uniqKey="Calder P" first="Philip C" last="Calder">Philip C. Calder</name><affiliation><nlm:affiliation>From Chr. Hansen A/S, Hørsholm, Denmark (LJ, IT, DE, CMM, and BM); Department of Nutrition, Exercise and Sports, Faculty of Science, University of Copenhagen, Copenhagen, Denmark (SB and LOD); Department of Sciences, Roosevelt Academy, Middelburg, The Netherlands (GTR); Human Development and Health Academic Unit, Faculty of Medicine, University of Southampton, Southampton, United Kingdom, and National Institute for Health Research Southampton Biomedical Research Centre, University Hospital Southampton National Health Service Foundation Trust and University of Southampton, Southampton, United Kingdom (PCC).</nlm:affiliation><wicri:noCountry code="subField">United Kingdom (PCC)</wicri:noCountry></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2015">2015</date><idno type="RBID">pubmed:25926507</idno><idno type="pmid">25926507</idno><idno type="doi">10.3945/ajcn.114.103531</idno><idno type="wicri:Area/Main/Corpus">000130</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000130</idno><idno type="wicri:Area/Main/Curation">000130</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Curation">000130</idno><idno type="wicri:Area/Main/Exploration">000130</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Effect of Lactobacillus paracasei subsp. paracasei, L. casei 431 on immune response to influenza vaccination and upper respiratory tract infections in healthy adult volunteers: a randomized, double-blind, placebo-controlled, parallel-group study.</title><author><name sortKey="Jespersen, Lillian" sort="Jespersen, Lillian" uniqKey="Jespersen L" first="Lillian" last="Jespersen">Lillian Jespersen</name><affiliation><nlm:affiliation>From Chr. Hansen A/S, Hørsholm, Denmark (LJ, IT, DE, CMM, and BM); Department of Nutrition, Exercise and Sports, Faculty of Science, University of Copenhagen, Copenhagen, Denmark (SB and LOD); Department of Sciences, Roosevelt Academy, Middelburg, The Netherlands (GTR); Human Development and Health Academic Unit, Faculty of Medicine, University of Southampton, Southampton, United Kingdom, and National Institute for Health Research Southampton Biomedical Research Centre, University Hospital Southampton National Health Service Foundation Trust and University of Southampton, Southampton, United Kingdom (PCC).</nlm:affiliation><wicri:noCountry code="subField">United Kingdom (PCC)</wicri:noCountry></affiliation></author><author><name sortKey="Tarnow, Inge" sort="Tarnow, Inge" uniqKey="Tarnow I" first="Inge" last="Tarnow">Inge Tarnow</name><affiliation><nlm:affiliation>From Chr. Hansen A/S, Hørsholm, Denmark (LJ, IT, DE, CMM, and BM); Department of Nutrition, Exercise and Sports, Faculty of Science, University of Copenhagen, Copenhagen, Denmark (SB and LOD); Department of Sciences, Roosevelt Academy, Middelburg, The Netherlands (GTR); Human Development and Health Academic Unit, Faculty of Medicine, University of Southampton, Southampton, United Kingdom, and National Institute for Health Research Southampton Biomedical Research Centre, University Hospital Southampton National Health Service Foundation Trust and University of Southampton, Southampton, United Kingdom (PCC).</nlm:affiliation><wicri:noCountry code="subField">United Kingdom (PCC)</wicri:noCountry></affiliation></author><author><name sortKey="Eskesen, Dorte" sort="Eskesen, Dorte" uniqKey="Eskesen D" first="Dorte" last="Eskesen">Dorte Eskesen</name><affiliation><nlm:affiliation>From Chr. Hansen A/S, Hørsholm, Denmark (LJ, IT, DE, CMM, and BM); Department of Nutrition, Exercise and Sports, Faculty of Science, University of Copenhagen, Copenhagen, Denmark (SB and LOD); Department of Sciences, Roosevelt Academy, Middelburg, The Netherlands (GTR); Human Development and Health Academic Unit, Faculty of Medicine, University of Southampton, Southampton, United Kingdom, and National Institute for Health Research Southampton Biomedical Research Centre, University Hospital Southampton National Health Service Foundation Trust and University of Southampton, Southampton, United Kingdom (PCC).</nlm:affiliation><wicri:noCountry code="subField">United Kingdom (PCC)</wicri:noCountry></affiliation></author><author><name sortKey="Morberg, Cathrine Melsaether" sort="Morberg, Cathrine Melsaether" uniqKey="Morberg C" first="Cathrine Melsaether" last="Morberg">Cathrine Melsaether Morberg</name><affiliation wicri:level="1"><nlm:affiliation>From Chr. Hansen A/S, Hørsholm, Denmark (LJ, IT, DE, CMM, and BM); Department of Nutrition, Exercise and Sports, Faculty of Science, University of Copenhagen, Copenhagen, Denmark (SB and LOD); Department of Sciences, Roosevelt Academy, Middelburg, The Netherlands (GTR); Human Development and Health Academic Unit, Faculty of Medicine, University of Southampton, Southampton, United Kingdom, and National Institute for Health Research Southampton Biomedical Research Centre, University Hospital Southampton National Health Service Foundation Trust and University of Southampton, Southampton, United Kingdom (PCC). dkcmm@chr-hansen.com.</nlm:affiliation><country wicri:rule="url">Oman</country></affiliation></author><author><name sortKey="Michelsen, Birgit" sort="Michelsen, Birgit" uniqKey="Michelsen B" first="Birgit" last="Michelsen">Birgit Michelsen</name><affiliation><nlm:affiliation>From Chr. Hansen A/S, Hørsholm, Denmark (LJ, IT, DE, CMM, and BM); Department of Nutrition, Exercise and Sports, Faculty of Science, University of Copenhagen, Copenhagen, Denmark (SB and LOD); Department of Sciences, Roosevelt Academy, Middelburg, The Netherlands (GTR); Human Development and Health Academic Unit, Faculty of Medicine, University of Southampton, Southampton, United Kingdom, and National Institute for Health Research Southampton Biomedical Research Centre, University Hospital Southampton National Health Service Foundation Trust and University of Southampton, Southampton, United Kingdom (PCC).</nlm:affiliation><wicri:noCountry code="subField">United Kingdom (PCC)</wicri:noCountry></affiliation></author><author><name sortKey="Bugel, Susanne" sort="Bugel, Susanne" uniqKey="Bugel S" first="Susanne" last="Bügel">Susanne Bügel</name><affiliation><nlm:affiliation>From Chr. Hansen A/S, Hørsholm, Denmark (LJ, IT, DE, CMM, and BM); Department of Nutrition, Exercise and Sports, Faculty of Science, University of Copenhagen, Copenhagen, Denmark (SB and LOD); Department of Sciences, Roosevelt Academy, Middelburg, The Netherlands (GTR); Human Development and Health Academic Unit, Faculty of Medicine, University of Southampton, Southampton, United Kingdom, and National Institute for Health Research Southampton Biomedical Research Centre, University Hospital Southampton National Health Service Foundation Trust and University of Southampton, Southampton, United Kingdom (PCC).</nlm:affiliation><wicri:noCountry code="subField">United Kingdom (PCC)</wicri:noCountry></affiliation></author><author><name sortKey="Dragsted, Lars Ove" sort="Dragsted, Lars Ove" uniqKey="Dragsted L" first="Lars Ove" last="Dragsted">Lars Ove Dragsted</name><affiliation><nlm:affiliation>From Chr. Hansen A/S, Hørsholm, Denmark (LJ, IT, DE, CMM, and BM); Department of Nutrition, Exercise and Sports, Faculty of Science, University of Copenhagen, Copenhagen, Denmark (SB and LOD); Department of Sciences, Roosevelt Academy, Middelburg, The Netherlands (GTR); Human Development and Health Academic Unit, Faculty of Medicine, University of Southampton, Southampton, United Kingdom, and National Institute for Health Research Southampton Biomedical Research Centre, University Hospital Southampton National Health Service Foundation Trust and University of Southampton, Southampton, United Kingdom (PCC).</nlm:affiliation><wicri:noCountry code="subField">United Kingdom (PCC)</wicri:noCountry></affiliation></author><author><name sortKey="Rijkers, Ger T" sort="Rijkers, Ger T" uniqKey="Rijkers G" first="Ger T" last="Rijkers">Ger T. Rijkers</name><affiliation><nlm:affiliation>From Chr. Hansen A/S, Hørsholm, Denmark (LJ, IT, DE, CMM, and BM); Department of Nutrition, Exercise and Sports, Faculty of Science, University of Copenhagen, Copenhagen, Denmark (SB and LOD); Department of Sciences, Roosevelt Academy, Middelburg, The Netherlands (GTR); Human Development and Health Academic Unit, Faculty of Medicine, University of Southampton, Southampton, United Kingdom, and National Institute for Health Research Southampton Biomedical Research Centre, University Hospital Southampton National Health Service Foundation Trust and University of Southampton, Southampton, United Kingdom (PCC).</nlm:affiliation><wicri:noCountry code="subField">United Kingdom (PCC)</wicri:noCountry></affiliation></author><author><name sortKey="Calder, Philip C" sort="Calder, Philip C" uniqKey="Calder P" first="Philip C" last="Calder">Philip C. Calder</name><affiliation><nlm:affiliation>From Chr. Hansen A/S, Hørsholm, Denmark (LJ, IT, DE, CMM, and BM); Department of Nutrition, Exercise and Sports, Faculty of Science, University of Copenhagen, Copenhagen, Denmark (SB and LOD); Department of Sciences, Roosevelt Academy, Middelburg, The Netherlands (GTR); Human Development and Health Academic Unit, Faculty of Medicine, University of Southampton, Southampton, United Kingdom, and National Institute for Health Research Southampton Biomedical Research Centre, University Hospital Southampton National Health Service Foundation Trust and University of Southampton, Southampton, United Kingdom (PCC).</nlm:affiliation><wicri:noCountry code="subField">United Kingdom (PCC)</wicri:noCountry></affiliation></author></analytic><series><title level="j">The American journal of clinical nutrition</title><idno type="eISSN">1938-3207</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Animals</term><term>Antibodies, Viral (blood)</term><term>Body Mass Index</term><term>Colony Count, Microbial</term><term>Denmark</term><term>Double-Blind Method</term><term>Female</term><term>Germany</term><term>Healthy Volunteers</term><term>Hemagglutination Inhibition Tests</term><term>Humans</term><term>Influenza Vaccines (therapeutic use)</term><term>Influenza, Human (immunology)</term><term>Influenza, Human (prevention & control)</term><term>Lactobacillus casei</term><term>Male</term><term>Middle Aged</term><term>Milk</term><term>Probiotics (administration & dosage)</term><term>Respiratory Tract Infections (immunology)</term><term>Respiratory Tract Infections (prevention & control)</term><term>Treatment Outcome</term><term>Vaccination</term><term>Young Adult</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adolescent</term><term>Adulte</term><term>Adulte d'âge moyen</term><term>Allemagne</term><term>Animaux</term><term>Anticorps antiviraux (sang)</term><term>Danemark</term><term>Femelle</term><term>Grippe humaine ()</term><term>Grippe humaine (immunologie)</term><term>Humains</term><term>Indice de masse corporelle</term><term>Infections de l'appareil respiratoire ()</term><term>Infections de l'appareil respiratoire (immunologie)</term><term>Jeune adulte</term><term>Lactobacillus casei</term><term>Lait</term><term>Mâle</term><term>Méthode en double aveugle</term><term>Numération de colonies microbiennes</term><term>Probiotiques (administration et posologie)</term><term>Résultat thérapeutique</term><term>Tests d'inhibition de l'hémagglutination</term><term>Vaccination</term><term>Vaccins antigrippaux (usage thérapeutique)</term><term>Volontaires sains</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Antibodies, Viral</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Influenza Vaccines</term></keywords><keywords scheme="MESH" type="geographic" xml:lang="en"><term>Denmark</term><term>Germany</term></keywords><keywords scheme="MESH" qualifier="administration & dosage" xml:lang="en"><term>Probiotics</term></keywords><keywords scheme="MESH" qualifier="administration et posologie" xml:lang="fr"><term>Probiotiques</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Grippe humaine</term><term>Infections de l'appareil respiratoire</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Influenza, Human</term><term>Respiratory Tract Infections</term></keywords><keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Influenza, Human</term><term>Respiratory Tract Infections</term></keywords><keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Anticorps antiviraux</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Vaccins antigrippaux</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Animals</term><term>Body Mass Index</term><term>Colony Count, Microbial</term><term>Double-Blind Method</term><term>Female</term><term>Healthy Volunteers</term><term>Hemagglutination Inhibition Tests</term><term>Humans</term><term>Lactobacillus casei</term><term>Male</term><term>Middle Aged</term><term>Milk</term><term>Treatment Outcome</term><term>Vaccination</term><term>Young Adult</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adolescent</term><term>Adulte</term><term>Adulte d'âge moyen</term><term>Allemagne</term><term>Animaux</term><term>Danemark</term><term>Femelle</term><term>Grippe humaine</term><term>Humains</term><term>Indice de masse corporelle</term><term>Infections de l'appareil respiratoire</term><term>Jeune adulte</term><term>Lactobacillus casei</term><term>Lait</term><term>Mâle</term><term>Méthode en double aveugle</term><term>Numération de colonies microbiennes</term><term>Résultat thérapeutique</term><term>Tests d'inhibition de l'hémagglutination</term><term>Vaccination</term><term>Volontaires sains</term></keywords><keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Danemark</term><term>Allemagne</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p><b>BACKGROUND</b></p><p>Probiotics can modulate the immune system in healthy individuals and may help reduce symptoms related to respiratory infections.</p></div><div type="abstract" xml:lang="en"><p><b>OBJECTIVE</b></p><p>The objective of the study was to investigate the effect of the probiotic strain Lactobacillus paracasei subsp. paracasei, L. casei 431 (Chr. Hansen A/S) (hereafter, L. casei 431) on immune response to influenza vaccination and respiratory symptoms in healthy adults.</p></div><div type="abstract" xml:lang="en"><p><b>DESIGN</b></p><p>A randomized double-blind, placebo-controlled trial was conducted in 1104 healthy subjects aged 18-60 y at 2 centers in Germany and Denmark. Subjects were randomly assigned to receive an acidified milk drink containing ≥10(9) colony-forming units of L. casei 431 (n = 553) or placebo (n = 551) for 42 d. After 21 d, subjects received the seasonal influenza vaccination. The primary outcome was seroprotection rate (anti-influenza antibody titers by hemagglutination inhibition) 21 d after vaccination. Other outcomes were seroconversion rate and mean titers, influenza A-specific antibodies and incidence, and duration and severity of upper respiratory symptoms. Antibiotic use and use of health care resources were recorded.</p></div><div type="abstract" xml:lang="en"><p><b>RESULTS</b></p><p>There was no effect of L. casei 431 on immune responses to influenza vaccination. Generalized linear mixed modeling showed a shorter duration of upper respiratory symptoms in the probiotic group than in the placebo group (mean ± SD: 6.4 ± 6.1 vs. 7.3 ± 9.7 d, P = 0.0059) in the last 3 wk of the intervention period. No statistically significant differences were found for incidence or severity.</p></div><div type="abstract" xml:lang="en"><p><b>CONCLUSIONS</b></p><p>Daily consumption of L. casei 431 resulted in no observable effect on the components of the immune response to influenza vaccination but reduced the duration of upper respiratory symptoms. The trial was registered at www.isrctn.com as ISRCTN08280229.</p></div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">25926507</PMID><DateCompleted><Year>2015</Year><Month>08</Month><Day>07</Day></DateCompleted><DateRevised><Year>2015</Year><Month>06</Month><Day>02</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1938-3207</ISSN><JournalIssue CitedMedium="Internet"><Volume>101</Volume><Issue>6</Issue><PubDate><Year>2015</Year><Month>Jun</Month></PubDate></JournalIssue><Title>The American journal of clinical nutrition</Title><ISOAbbreviation>Am. J. Clin. Nutr.</ISOAbbreviation></Journal><ArticleTitle>Effect of Lactobacillus paracasei subsp. paracasei, L. casei 431 on immune response to influenza vaccination and upper respiratory tract infections in healthy adult volunteers: a randomized, double-blind, placebo-controlled, parallel-group study.</ArticleTitle><Pagination><MedlinePgn>1188-96</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.3945/ajcn.114.103531</ELocationID><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Probiotics can modulate the immune system in healthy individuals and may help reduce symptoms related to respiratory infections.</AbstractText><AbstractText Label="OBJECTIVE" NlmCategory="OBJECTIVE">The objective of the study was to investigate the effect of the probiotic strain Lactobacillus paracasei subsp. paracasei, L. casei 431 (Chr. Hansen A/S) (hereafter, L. casei 431) on immune response to influenza vaccination and respiratory symptoms in healthy adults.</AbstractText><AbstractText Label="DESIGN" NlmCategory="METHODS">A randomized double-blind, placebo-controlled trial was conducted in 1104 healthy subjects aged 18-60 y at 2 centers in Germany and Denmark. Subjects were randomly assigned to receive an acidified milk drink containing ≥10(9) colony-forming units of L. casei 431 (n = 553) or placebo (n = 551) for 42 d. After 21 d, subjects received the seasonal influenza vaccination. The primary outcome was seroprotection rate (anti-influenza antibody titers by hemagglutination inhibition) 21 d after vaccination. Other outcomes were seroconversion rate and mean titers, influenza A-specific antibodies and incidence, and duration and severity of upper respiratory symptoms. Antibiotic use and use of health care resources were recorded.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">There was no effect of L. casei 431 on immune responses to influenza vaccination. Generalized linear mixed modeling showed a shorter duration of upper respiratory symptoms in the probiotic group than in the placebo group (mean ± SD: 6.4 ± 6.1 vs. 7.3 ± 9.7 d, P = 0.0059) in the last 3 wk of the intervention period. No statistically significant differences were found for incidence or severity.</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">Daily consumption of L. casei 431 resulted in no observable effect on the components of the immune response to influenza vaccination but reduced the duration of upper respiratory symptoms. The trial was registered at www.isrctn.com as ISRCTN08280229.</AbstractText><CopyrightInformation>© 2015 American Society for Nutrition.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Jespersen</LastName><ForeName>Lillian</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>From Chr. Hansen A/S, Hørsholm, Denmark (LJ, IT, DE, CMM, and BM); Department of Nutrition, Exercise and Sports, Faculty of Science, University of Copenhagen, Copenhagen, Denmark (SB and LOD); Department of Sciences, Roosevelt Academy, Middelburg, The Netherlands (GTR); Human Development and Health Academic Unit, Faculty of Medicine, University of Southampton, Southampton, United Kingdom, and National Institute for Health Research Southampton Biomedical Research Centre, University Hospital Southampton National Health Service Foundation Trust and University of Southampton, Southampton, United Kingdom (PCC).</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tarnow</LastName><ForeName>Inge</ForeName><Initials>I</Initials><AffiliationInfo><Affiliation>From Chr. Hansen A/S, Hørsholm, Denmark (LJ, IT, DE, CMM, and BM); Department of Nutrition, Exercise and Sports, Faculty of Science, University of Copenhagen, Copenhagen, Denmark (SB and LOD); Department of Sciences, Roosevelt Academy, Middelburg, The Netherlands (GTR); Human Development and Health Academic Unit, Faculty of Medicine, University of Southampton, Southampton, United Kingdom, and National Institute for Health Research Southampton Biomedical Research Centre, University Hospital Southampton National Health Service Foundation Trust and University of Southampton, Southampton, United Kingdom (PCC).</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Eskesen</LastName><ForeName>Dorte</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>From Chr. Hansen A/S, Hørsholm, Denmark (LJ, IT, DE, CMM, and BM); Department of Nutrition, Exercise and Sports, Faculty of Science, University of Copenhagen, Copenhagen, Denmark (SB and LOD); Department of Sciences, Roosevelt Academy, Middelburg, The Netherlands (GTR); Human Development and Health Academic Unit, Faculty of Medicine, University of Southampton, Southampton, United Kingdom, and National Institute for Health Research Southampton Biomedical Research Centre, University Hospital Southampton National Health Service Foundation Trust and University of Southampton, Southampton, United Kingdom (PCC).</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Morberg</LastName><ForeName>Cathrine Melsaether</ForeName><Initials>CM</Initials><AffiliationInfo><Affiliation>From Chr. Hansen A/S, Hørsholm, Denmark (LJ, IT, DE, CMM, and BM); Department of Nutrition, Exercise and Sports, Faculty of Science, University of Copenhagen, Copenhagen, Denmark (SB and LOD); Department of Sciences, Roosevelt Academy, Middelburg, The Netherlands (GTR); Human Development and Health Academic Unit, Faculty of Medicine, University of Southampton, Southampton, United Kingdom, and National Institute for Health Research Southampton Biomedical Research Centre, University Hospital Southampton National Health Service Foundation Trust and University of Southampton, Southampton, United Kingdom (PCC). dkcmm@chr-hansen.com.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Michelsen</LastName><ForeName>Birgit</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>From Chr. Hansen A/S, Hørsholm, Denmark (LJ, IT, DE, CMM, and BM); Department of Nutrition, Exercise and Sports, Faculty of Science, University of Copenhagen, Copenhagen, Denmark (SB and LOD); Department of Sciences, Roosevelt Academy, Middelburg, The Netherlands (GTR); Human Development and Health Academic Unit, Faculty of Medicine, University of Southampton, Southampton, United Kingdom, and National Institute for Health Research Southampton Biomedical Research Centre, University Hospital Southampton National Health Service Foundation Trust and University of Southampton, Southampton, United Kingdom (PCC).</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bügel</LastName><ForeName>Susanne</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>From Chr. Hansen A/S, Hørsholm, Denmark (LJ, IT, DE, CMM, and BM); Department of Nutrition, Exercise and Sports, Faculty of Science, University of Copenhagen, Copenhagen, Denmark (SB and LOD); Department of Sciences, Roosevelt Academy, Middelburg, The Netherlands (GTR); Human Development and Health Academic Unit, Faculty of Medicine, University of Southampton, Southampton, United Kingdom, and National Institute for Health Research Southampton Biomedical Research Centre, University Hospital Southampton National Health Service Foundation Trust and University of Southampton, Southampton, United Kingdom (PCC).</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Dragsted</LastName><ForeName>Lars Ove</ForeName><Initials>LO</Initials><AffiliationInfo><Affiliation>From Chr. Hansen A/S, Hørsholm, Denmark (LJ, IT, DE, CMM, and BM); Department of Nutrition, Exercise and Sports, Faculty of Science, University of Copenhagen, Copenhagen, Denmark (SB and LOD); Department of Sciences, Roosevelt Academy, Middelburg, The Netherlands (GTR); Human Development and Health Academic Unit, Faculty of Medicine, University of Southampton, Southampton, United Kingdom, and National Institute for Health Research Southampton Biomedical Research Centre, University Hospital Southampton National Health Service Foundation Trust and University of Southampton, Southampton, United Kingdom (PCC).</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Rijkers</LastName><ForeName>Ger T</ForeName><Initials>GT</Initials><AffiliationInfo><Affiliation>From Chr. Hansen A/S, Hørsholm, Denmark (LJ, IT, DE, CMM, and BM); Department of Nutrition, Exercise and Sports, Faculty of Science, University of Copenhagen, Copenhagen, Denmark (SB and LOD); Department of Sciences, Roosevelt Academy, Middelburg, The Netherlands (GTR); Human Development and Health Academic Unit, Faculty of Medicine, University of Southampton, Southampton, United Kingdom, and National Institute for Health Research Southampton Biomedical Research Centre, University Hospital Southampton National Health Service Foundation Trust and University of Southampton, Southampton, United Kingdom (PCC).</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Calder</LastName><ForeName>Philip C</ForeName><Initials>PC</Initials><AffiliationInfo><Affiliation>From Chr. Hansen A/S, Hørsholm, Denmark (LJ, IT, DE, CMM, and BM); Department of Nutrition, Exercise and Sports, Faculty of Science, University of Copenhagen, Copenhagen, Denmark (SB and LOD); Department of Sciences, Roosevelt Academy, Middelburg, The Netherlands (GTR); Human Development and Health Academic Unit, Faculty of Medicine, University of Southampton, Southampton, United Kingdom, and National Institute for Health Research Southampton Biomedical Research Centre, University Hospital Southampton National Health Service Foundation Trust and University of Southampton, Southampton, United Kingdom (PCC).</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><DataBankList CompleteYN="Y"><DataBank><DataBankName>ISRCTN</DataBankName><AccessionNumberList><AccessionNumber>ISRCTN08280229</AccessionNumber></AccessionNumberList></DataBank></DataBankList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D016448">Multicenter Study</PublicationType><PublicationType UI="D016449">Randomized Controlled Trial</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2015</Year><Month>04</Month><Day>29</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Am J Clin Nutr</MedlineTA><NlmUniqueID>0376027</NlmUniqueID><ISSNLinking>0002-9165</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000914">Antibodies, Viral</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D007252">Influenza Vaccines</NameOfSubstance></Chemical></ChemicalList><CitationSubset>AIM</CitationSubset><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000293" MajorTopicYN="N">Adolescent</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000914" MajorTopicYN="N">Antibodies, Viral</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="N">blood</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D015992" MajorTopicYN="N">Body Mass Index</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D015169" MajorTopicYN="N">Colony Count, Microbial</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D003718" MajorTopicYN="N" Type="Geographic">Denmark</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D004311" MajorTopicYN="N">Double-Blind Method</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005858" MajorTopicYN="N" Type="Geographic">Germany</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D064368" MajorTopicYN="N">Healthy Volunteers</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006385" MajorTopicYN="N">Hemagglutination Inhibition Tests</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007252" MajorTopicYN="N">Influenza Vaccines</DescriptorName><QualifierName UI="Q000627" MajorTopicYN="N">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D007251" MajorTopicYN="N">Influenza, Human</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName><QualifierName UI="Q000517" MajorTopicYN="N">prevention & control</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D007780" MajorTopicYN="Y">Lactobacillus casei</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008892" MajorTopicYN="N">Milk</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D019936" MajorTopicYN="N">Probiotics</DescriptorName><QualifierName UI="Q000008" MajorTopicYN="Y">administration & dosage</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D012141" MajorTopicYN="N">Respiratory Tract Infections</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName><QualifierName UI="Q000517" MajorTopicYN="Y">prevention & control</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D016896" MajorTopicYN="N">Treatment Outcome</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D014611" MajorTopicYN="Y">Vaccination</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D055815" MajorTopicYN="N">Young Adult</DescriptorName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">L. casei 431</Keyword><Keyword MajorTopicYN="N">Lactobacillus paracasei subsp. paracasei</Keyword><Keyword MajorTopicYN="N">immune function</Keyword><Keyword MajorTopicYN="N">probiotics</Keyword><Keyword MajorTopicYN="N">upper respiratory tract infection</Keyword><Keyword MajorTopicYN="N">vaccination response</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2014</Year><Month>11</Month><Day>18</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2015</Year><Month>03</Month><Day>31</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2015</Year><Month>5</Month><Day>1</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2015</Year><Month>5</Month><Day>1</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2015</Year><Month>8</Month><Day>8</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">25926507</ArticleId><ArticleId IdType="pii">ajcn.114.103531</ArticleId><ArticleId IdType="doi">10.3945/ajcn.114.103531</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Oman</li></country></list><tree><noCountry><name sortKey="Bugel, Susanne" sort="Bugel, Susanne" uniqKey="Bugel S" first="Susanne" last="Bügel">Susanne Bügel</name><name sortKey="Calder, Philip C" sort="Calder, Philip C" uniqKey="Calder P" first="Philip C" last="Calder">Philip C. Calder</name><name sortKey="Dragsted, Lars Ove" sort="Dragsted, Lars Ove" uniqKey="Dragsted L" first="Lars Ove" last="Dragsted">Lars Ove Dragsted</name><name sortKey="Eskesen, Dorte" sort="Eskesen, Dorte" uniqKey="Eskesen D" first="Dorte" last="Eskesen">Dorte Eskesen</name><name sortKey="Jespersen, Lillian" sort="Jespersen, Lillian" uniqKey="Jespersen L" first="Lillian" last="Jespersen">Lillian Jespersen</name><name sortKey="Michelsen, Birgit" sort="Michelsen, Birgit" uniqKey="Michelsen B" first="Birgit" last="Michelsen">Birgit Michelsen</name><name sortKey="Rijkers, Ger T" sort="Rijkers, Ger T" uniqKey="Rijkers G" first="Ger T" last="Rijkers">Ger T. Rijkers</name><name sortKey="Tarnow, Inge" sort="Tarnow, Inge" uniqKey="Tarnow I" first="Inge" last="Tarnow">Inge Tarnow</name></noCountry><country name="Oman"><noRegion><name sortKey="Morberg, Cathrine Melsaether" sort="Morberg, Cathrine Melsaether" uniqKey="Morberg C" first="Cathrine Melsaether" last="Morberg">Cathrine Melsaether Morberg</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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